Genomics of postvaccination SARS-CoV-2 infections during the Delta dominated second wave of COVID-19 pandemic, from Mumbai Metropolitan Region (MMR), India델타가 인도 뭄바이 대도시 지역(MMR)에서 발생한 COVID-19 대유행의 두 번째 물결을 지배하는 동안 백신 접종 후 SARS-CoV-2 감염의 게놈Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed association B.1.617.2 clade collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient Delta delta variant Delta+ demographics disease severity Epidemiology form genetics Genomics Home isolation hospital increase in India Infection initiated K417N Lineage lineages MMR Mumbai Mutation mutations nanopore sequencing nucleocapsid ORF1a Oxford Patient postvaccination predominant progressed proportion reduction in Region Sample SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection second wave selected sequence sequenced sequences severe acute respiratory syndrome Coronavirus shown the disease vaccination Vaccination Status variant viral genome viral genomes virus virus classification virus classification. Wave [DOI] 10.1002/jmv.27861 PMC 바로가기 [Article Type] Article
Genomic epidemiology and emergence of SARS-CoV-2 variants of concern in the United Arab Emirates Research Published on 2022-08-292022-10-05 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] A.23.1 adopted Analysis B.1 B.1.1 B.1.1.7 B.1.351 clade collected contribute demonstrated epidemiological Epidemiology Frequency highest Hospitalization Hospitalized International Local measure Measures Mutation occur ORF1a outbreak pandemic positive proportion provide public health authority reduce RT-PCR SARS-CoV-2 SARS-CoV-2 variant sequenced Seven significantly Spread Surveillance Transmission transmission of SARS-CoV-2 United Arab Emirate variants variants of concern variants of interest viral sequence VoC VOCs VOI VOIs [DOI] 10.1038/s41598-022-16967-w [Article Type] Research
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern우려되는 모든 SARS-CoV-2 변이체의 유연한 검출을 위한 다중 단편 분석Article Published on 2022-07-272022-09-11 Journal: Clinical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] ABI Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis analyzed approach approach capillary electrophoresis concern coronavirus cycle threshold deleted Deletion Delta detection effective equipment exhibited fluorescent fragment insertion insertions Lambda limit of detection multiplex mutants omicron ORF1a ORF8 PCR performed primer primer pair primer pairs RDR RDR1 RDR2 RDR3 Receptor binding domain resolved respiratory specimens S-gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity subsequent target variant variants variants of concern VoC VOCs WGS whole genome Whole genome sequencing [DOI] 10.1093/clinchem/hvac081 PMC 바로가기 [Article Type] Article
Spread of endemic SARS-CoV-2 lineages in Russia before April 20212021년 4월 이전 러시아의 고유 SARS-CoV-2 계통 확산Article Published on 2022-07-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha B.1.1 B.1.1.7 B.1.351 Beta characterized Combination combinations country COVID-19 cases COVID-19 pandemic Deletion deletions delta variant Endemic Evidence Frequency highest hotspot identify indicate joint Lineage lineages Mutation mutations notable NSP6 ORF1a P.1 pandemic PCR testing remained Russia SARS-CoV-2 lineage spike glycoprotein Spread spring summer the epidemic Transmissibility variant variants variants of concern [DOI] 10.1371/journal.pone.0270717 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection일반적인 TCRαβ 모티프를 가진 SARS-CoV-2-특이 T 세포 기억은 감염 후 혈청 전환되는 예방접종을 받지 않은 어린이에서 확립됩니다Article Published on 2022-07-122022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults analyzed B cells CD4 CD4(+) T cells CD8 CD8(+) T cells Cell children circulating clonal expansion comparable convalescent coronavirus COVID-19 Epitopes Ex vivo HLA class I Infection memory memory T memory T cell memory T cells motif ORF1a phenotype presenting recruited reduced respiratory response SARS-CoV-2 SARS-CoV-2 epitopes seroconvert seroconverted Seven severe acute respiratory syndrome Coronavirus stem cell T cell T cell memory T cell receptor T cells TCR sequencing tetramer tetramer-specific. to define vaccination virus [DOI] 10.1016/j.immuni.2022.06.003 PMC 바로가기 [Article Type] Article
Active surveillance and early detection of community transmission of SARS-CoV-2 Mu variant (B.1.621) in the Brazilian Amazon브라질 아마존에서 SARS-CoV-2 Mu 변종(B.1.621) 지역사회 전파에 대한 능동적 감시 및 조기 탐지Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Active surveillance All participants Amino acid amino acid substitution Antigen assist Asymptomatic B.1.621 blood sample Blood samples Brazilian Amazon Chain Reaction circulating city collected Community community transmission Contact tracing country COVID-19 patient Diagnosis diagnostic test ELISA testing Emergency epidemiological data followed by genomic genomic sequencing Genomic surveillance highlight household contacts identify IgA IgG IgG levels IgM antibody IgM antibody levels individual infected individual information mild symptoms Mu variant nasopharyngeal swabs one patient ORF1a ORF7a outpatients Participants polymerase chain reaction Porto prospective cohort Rapid diagnostic test reference sequence Reverse transcription-polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. sequenced specimen Surveillance Swab tested Travel variant virus virus viruses [DOI] 10.1002/jmv.27686 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka스리랑카에서 AY.28 및 AY.104 델타 하위 계통의 분자 역학Article Published on 2022-06-212022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V absence Analysis analyzed AY.104 AY.28 B.1.617.2 characterized clinical disease clinical implication clinical implications COVID-19 Delta delta variant determine dominant variant duration of hospitalization Epidemiology expression expression level genomic Illumina individual Infection investigated Laboratory Lineage lineages Mutation no difference ORF1a ORF3 ORF3a ORF6 outbreak Oxford parental periscope Prevalence RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequenced Seven severe disease severity sgRNA significantly higher Spike protein sub genomic RNA sub lineages. the spike protein variant [DOI] 10.3389/fpubh.2022.873633 PMC 바로가기 [Article Type] Article
Genomic Epidemiology of Imported Cases of COVID-19 in Guangdong Province, China, October 2020 – May 20212020년 10월 - 2021년 5월 중국 광둥성에서 수입된 COVID-19 사례의 게놈 역학Article Published on 2022-05-202022-09-11 Journal: Biomedical and environmental sciences : BES [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid analysis analyzed Asian B.1.1.7 B.1.351 Characteristics China Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients D614G mutation detect Diversity Europe evaluate evaluated Frame Frequency genome sequence Government Guangdong Guangzhou hazard High-throughput sequencing High-throughput sequencing technology highest homology infected with SARS-CoV-2 Influenza initiative Lineage lineages Missense mutations molecular MOST Mutation Next-generation sequencing North America nucleotide occurred Open reading frame ORF1a ORF7b Orf9b pandemic pangolin Patient peaking Phylogenetic tree proportion Protein reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein suggested the spike protein The United States throat swab treat United States variant variants variants. viral sequence viral sequences was used were used [DOI] 10.3967/bes2022.055 PMC 바로가기 [Article Type] Article
[SARS-CoV-2 with transcription regulatory sequence motif mutation poses a greater threat][전사 조절 서열 모티브 돌연변이를 가진 SARS-CoV-2는 더 큰 위협이 된다]Article Published on 2022-03-202022-09-11 Journal: Nan fang yi ke da xue xue bao = Journal of Souther [Category] SARS, 변종, 치료기술, [키워드] Analysis Asia Asymptomatic B.1.617.2 change Chinese cleavage consensus sequence CoV CoV genome Cross-species transmission defined Delta delta variant detection rate English functional genomic data greater humans increase in Incubation period mild infections molecular motif Mutation mutations NSP15 cleavage site nucleotide occur ORF1a outbreak Outbreaks Pandemics Prevention and control regulatory sequences residue SARS-CoV-2 SARS-CoV-2 transmission shown significantly Singapore Spread super-attenuated variant. Transcription transcription regulatory sequence Transcription Regulatory Sequences Transmission TRS TRS-B TRS-L TRSs upstream UTR variant variants variants of SARS-CoV-2 virus viruses was performed [DOI] 10.12122/j.issn.1673-4254.2022.03.12 PMC 바로가기 [Article Type] Article
Inferring transmission fitness advantage of SARS-CoV-2 variants of concern from wastewater samples using digital PCR, Switzerland, December 2020 through March 20212020년 12월부터 2021년 3월까지 디지털 PCR을 사용하여 폐수 샘플에서 우려되는 SARS-CoV-2 변종의 전파 적합성 이점 추론Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] SARS, 변종, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval aligning Alpha Analysis antibody approach B.1.1.7 Beta characteristic clinical samples COVID-19 pandemic Deletion digital PCR drop drop-off assays Frequency Gamma Genetic variant increasingly Infection Inference Mutation neutralisation offer ORF1 ORF1a PCR assay PCR assays quantification R package Real-time monitoring reduced relative frequency SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Spread statistical Surveillance Switzerland temporal dynamics Transmissibility Transmission transmission fitness. vaccination virulence VoC VOCs wastewater whole genome Whole genome sequencing Δ69-70 [DOI] 10.2807/1560-7917.ES.2022.27.10.2100806 PMC 바로가기 [Article Type] Article